TMLB-C16 | B3GAT3 inhibitor | Probechem Biochemicals

Chemical Structure : TMLB-C16

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TMLB-C16 (B3GAT3 inhibitor)

货号: PC-22571Not For Human Use, Lab Use Only.

TMLB-C16 is a potent beta-1,3-glucuronosyltransferase (B3GAT3) inhibitor with KD of 3.96 uM, suppresses proliferation and migration in HCC cells.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

TMLB-C16 is a potent beta-1,3-glucuronosyltransferase (B3GAT3) inhibitor with KD of 3.96 uM, suppresses proliferation and migration in HCC cells.
TMLB-C16 inhibits proliferation and migration, and induces cell cycle arrest and apoptosis in MHCC-97H (IC50= 6.53 μM) and HCCLM3 (IC50= 6.22 μM) cells.
TMLB-C16 demonstrated favorable pharmacokinetic properties with a relatively high bioavailability of 68.37%.
TMLB-C16 significantly inhibited tumor growth in both MHCC-97H and HCCLM3 xenograft tumor models without causing obvious toxicity.

物理化学性质&存储条件

分子量	453.88
分子式	C23H20ClN3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 3-(2-((1-(2-chloro-4-methylphenyl)-2-oxopyrrolidin-3-yl)amino)-2-oxoacetyl)-1H-indole-5-carboxylate

参考文献

1. Hao Yin, et al. J Med Chem. 2024 Jun 25. doi: 10.1021/acs.jmedchem.4c00242.