TMEM16A blocker 1PBC | TMEM16A blocker | Probechem Biochemicals

Chemical Structure : TMEM16A blocker 1PBC

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TMEM16A blocker 1PBC (TMEM16A blocker)

货号: PC-49192Not For Human Use, Lab Use Only.

1PBC is a small molecule blocker of calcium-activated chloride channel TMEM16A, blocks TMEM16A completely with an IC50 of 4 uM at zero mV and saturating Ca2+ concentration (2 uM).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

1PBC is a small molecule blocker of calcium-activated chloride channel TMEM16A, blocks TMEM16A completely with an IC50 of 4 uM at zero mV and saturating Ca2+ concentration (2 uM).
1PBC inhibits WT TMEM16A with micromolar range potentcy (IC50=13.1 uM), mutants R617A and R784A confers greater potency to 1PBC compared with the WT (IC50, 2.2 and 5.8 uM).
1PBC binds with an apparent valence of ~0.27 and a Kd of ~3.6 µM at zero mV.

物理化学性质&存储条件

分子量	277.206
分子式	C13H6F3N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Hydroxy-3-(trifluoromethyl)pyrido[1,2-a]benzimidazole-4-carbonitrile

参考文献

1. Christian J Peters, et al. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3547-52.

2. Andy K M Lam, et al. Nat Commun. 2022 May 19;13(1):2798.