TMEM16A activator E(act) | TMEM16A activator | Probechem Biochemicals

Chemical Structure : TMEM16A activator E(act)

CAS No.: 461000-66-8

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TMEM16A activator E(act) (Eact)

货号: PC-23882Not For Human Use, Lab Use Only.

TMEM16A activator E(act) (Eact) is a small molecule activator of calcium-activated chloride channel TMEM16A (ANO1) with EC50 of 3 uM.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
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100 mg		Get quote

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生物&药学活性

TMEM16A activator E(act) (Eact) is a small molecule activator of calcium-activated chloride channel TMEM16A (ANO1) with EC50 of 3 uM.
E(act) is effective in producing Cl− current in mouse TMEM16A.
E(act) shows activation by Eact of TMEM16B, the other TMEM16 isoform having CaCC activity, does not affect CFTR Cl− conductance or ENaC Na+ conductance.
E(act) inhibits TMEM16A Cl− conductance, providing further evidence for direct TMEM16A binding.
E(act) increases CaCC conductance in human salivary and airway submucosal gland epithelial cells, and IL-4 treated bronchial cells, and stimulates submucosal gland secretion in human bronchi and smooth muscle contraction in mouse intestine.

物理化学性质&存储条件

分子量	442.53
分子式	C23H26N2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-methoxyethyl)-N-(4-phenyl-2-thiazolyl)-2,3,4-trimethoxybenzeneacetamide

参考文献

1. Wan Namkung, et al. FASEB J. 2011 Nov;25(11):4048-62.

TMEM16A activator E(act) (Eact)

生物&药学活性

物理化学性质&存储条件

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TMEM16A activator E(act) (Eact)

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物理化学性质&存储条件

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