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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Calcium Channel -TMDJ-035
TMDJ-035

Chemical Structure : TMDJ-035

CAS No.: 2681302-83-8

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TMDJ-035 (TMDJ 035, TMDJ035)

货号: PC-21312Not For Human Use, Lab Use Only.

TMDJ-035 is the first highly potent and selective ryanodine receptor 2 (RyR2) inhibitor with EC50 of 13 nM, shows no effect on RyR1 and RyR3.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

TMDJ-035 is the first highly potent and selective ryanodine receptor 2 (RyR2) inhibitor with EC50 of 13 nM, shows no effect on RyR1 and RyR3.
TMDJ-035 (30-100 nM) is effective in preventing generation of Ca2+ waves in cardiomyocytes without affecting action potential-induced Ca2+ transients.
TMDJ-035 is a promising candidate for drug development to treat potentially fatal RyR2-related cardiac arrhythmias.

物理化学性质&存储条件

分子量 347.30
分子式 C16H12F3N5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(5-(3,5-Difluorophenyl)-2H-tetrazol-2-yl)-N-(4-fluorophenyl)-N-methylacetamide

参考文献

1. Ishida R, et al. Eur J Med Chem. 2023 Oct 25;262:115910.

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