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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HIV-TMC-126
TMC-126

Chemical Structure : TMC-126

CAS No.: 206362-00-7

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TMC-126 (UIC-94003, TMC126)

货号: PC-26785Not For Human Use, Lab Use Only.

TMC-126 (UIC-94003) is a potent, nonpeptidic human immunodeficiency virus (HIV) protease inhibitor, suppresses a wide spectrum of HIV-1, HIV-2, and various clinical HIV-1 strains with IC50 of 0.3-5.5 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

TMC-126 (UIC-94003) is a potent, nonpeptidic human immunodeficiency virus (HIV) protease inhibitor, suppresses a wide spectrum of HIV-1, HIV-2, and various clinical HIV-1 strains with IC50 of 0.3-5.5 nM.

物理化学性质&存储条件

分子量 562.68
分子式 C28H38N2O8S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Carbamic acid, N-[(1S,2R)-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-(phenylmethyl)propyl]-, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester

参考文献

1. Yoshimura K, et al. J Virol. 2002 Feb;76(3):1349-58.

2. Ghosh, A. K., et al. 1998. Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere. Bioorg. Med. Chem. Lett. 8:687–690.

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