TM5614

Chemical Structure : TM5614

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货号: PC-22551Not For Human Use, Lab Use Only.

TM5614 is a specific PAI-1 inhibitor with an IC50 value of 3.63 μM in a tPA-dependent hydrolysis assay.

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生物&药学活性

TM5614 is a specific PAI-1 inhibitor with an IC50 value of 3.63 μM in a tPA-dependent hydrolysis assay.
TM5614 treatment significantly suppressed cell proliferation and induced apoptosis in K562/PAI-1 cells, accompanied by increased activity of Furin protease, which is a known target of PAI-1.
TM5614 significantly ameliorates PM(2.5)-induced vascular thrombosis.
TM5614 ameliorates hypophosphatemia in Hyp mice.

物理化学性质&存储条件

分子量	402.83
分子式	C23H15ClN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-chloro-2-(3-(quinolin-8-yl)benzamido)benzoic acid

参考文献

1. Nagahisa Yamaoka, et al. Bioorg Med Chem Lett. 2018 Feb 15;28(4):809-813.

2. Qian C, et al. FEBS Open Bio. 2024 Feb;14(2):290-299.

3. Sasaki K, et al. Tohoku J Exp Med. 2022 Jun 25;257(3):211-224.

TM5614

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物理化学性质&存储条件

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TM5614

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