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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Plasminogen Activator Inhibitor-1 (PAI-1)-TM5441
TM5441

Chemical Structure : TM5441

CAS No.: 1190221-43-2

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TM5441 (TM-5441)

货号: PC-21332Not For Human Use, Lab Use Only.

TM5441 is a specific, orally active, small molecule inhibitor of plasminogen activator inhibitor 1 (PAI-1, Serpin E1), TM5441 is as effective as complete deficiency of PAI-1 in protecting against L-NAME-induced pathologies.

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10 mg ￥1780 In stock
25 mg ￥2980 In stock
50 mg ￥4580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TM5441 is a specific, orally active, small molecule inhibitor of plasminogen activator inhibitor 1 (PAI-1, Serpin E1), TM5441 is as effective as complete deficiency of PAI-1 in protecting against L-NAME-induced pathologies.
TM5441 does not inhibit other SERPINs such as antithrombin III and α2-antiplasmin.
TM5441 reduces cardiac hypertrophy derived from L-NAME treatment and prevents the development of periaortic fibrosis.
TM5441 protects against L-NAME-induced vascular senescence in vivo.

物理化学性质&存储条件

分子量 428.83
分子式 C21H17ClN2O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-Chloro-2-(2-(2-((3-(furan-3-yl)phenyl)amino)-2-oxoethoxy)acetamido)benzoic acid

参考文献

1. Boe AE, et al. Circulation. 2013 Nov 19;128(21):2318-24.

2. Eren M, et al. Proc Natl Acad Sci U S A. 2014 May 13;111(19):7090-5.

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