TM2-115 |CAS:1197196-47-6 Probechem Biochemicals

Chemical Structure : TM2-115

CAS No.: 1197196-47-6

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TM2-115 (TM2 115)

货号: PC-70359Not For Human Use, Lab Use Only.

TM2-115 is a BIX-01294 derivative that inhibit malaria parasite histone methyltransferases, resulting in rapid and irreversible parasite death.

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5 mg	￥1180	In stock
10 mg	￥1780	In stock
25 mg	￥2880	In stock
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100 mg		Get quote

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生物&药学活性

TM2-115 is a BIX-01294 derivative that inhibit malaria parasite histone methyltransferases, resulting in rapid and irreversible parasite death.
TM2-115 inhibits P. falciparum 3D7 parasites in culture with IC50 of 100 nM, >22-fold more potent than IC50 toward two human cell lines and one mouse cell line.
TM2-115 significant reduces histone H3K4me3 levels in a concentration-dependent and exposure time-dependent manner in treatment of P. falciparum parasites.

物理化学性质&存储条件

分子量	489.664
分子式	C29H39N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(benzyloxy)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine

参考文献

1. Malmquist NA, et al. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16708-13.

2. Malmquist NA, et al. Antimicrob Agents Chemother. 2015 Feb;59(2):950-9.

TM2-115 (TM2 115)

生物&药学活性

物理化学性质&存储条件

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TM2-115 (TM2 115)

生物&药学活性

物理化学性质&存储条件

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