TM-N1324 | GPR39 agonist | Probechem Biochemicals

Chemical Structure : TM-N1324

CAS No.: 1144477-35-9

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TM-N1324 (GPR39 agonist Cpd1324)

货号: PC-38251Not For Human Use, Lab Use Only.

GPR39 agonist Cpd1324 (TM-N1324) is a potent, selective, orally active GPR39 agonist, activats human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively.

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5 mg	￥980	In stock
10 mg	￥1580	In stock
25 mg	￥2780	In stock
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生物&药学活性

GPR39 agonist Cpd1324 (TM-N1324) is a potent, selective, orally active GPR39 agonist, activats human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively.
GPR39 agonist Cpd1324 (TM-N1324) shows clean off-target activities using a panel of 165 GPCRs, i.e., the Millipore GPCR-profiler service, and has similar potencies on murine GPR39 (180 nM and 5 nM, in the absence and presence of Zn2+).
GPR39 agonist Cpd1324 increased GLP-1 secretion in the mice as well as in mouse and human intestinal organoids, but not in GPR39 KO mouse organoids.

物理化学性质&存储条件

分子量	397.798
分子式	C18H13ClFN7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-chloro-4-fluorophenyl)-3-methyl-1-(9H-purin-6-yl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-one

参考文献

1. Grunddal KV, et al. Mol Metab. 2021 Jul;49:101207.

2. Thomas M Frimurer, et al. J Med Chem. 2017 Feb 9;60(3):886-898.

TM-N1324 (GPR39 agonist Cpd1324)

生物&药学活性

物理化学性质&存储条件

参考文献

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TM-N1324 (GPR39 agonist Cpd1324)

生物&药学活性

物理化学性质&存储条件

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