TLR8 antagonist 35

Chemical Structure : TLR8 antagonist 35

加入收藏

货号: PC-26536Not For Human Use, Lab Use Only.

TLR8 antagonist 35 is a potent, selective TLR8 antagonist with IC50 of 32 nM in hTLR8-HEK293 reporter cells.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

TLR8 antagonist 35 is a potent, selective TLR8 antagonist with IC50 of 32 nM in hTLR8-HEK293 reporter cells.
TLR8 antagonist 35 shows 290- and 67-fold selectivity over hTLR7-and hTLR9-overexpressing cells.
TLR8 antagonist 35 demonstrates concentration-dependent inhibition of TNF secretion with IC50 of 14 nM in THP-1 macrophages and 107 nM in PBMCs, completely inhibits TL8-506-induced IL-8 secretion at 1 uM.
TLR8 antagonist 35 induces concentration-dependent reduction in cellular responses TLR8-stimulated THP-1 macrophages with IC50 of 2.2 nM.

物理化学性质&存储条件

分子量	418.54
分子式	C25H30N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-Isopropylpiperidin-4-yl)-4-(((2-methylquinazolin-4-yl)oxy)methyl)benzamide

参考文献

1. Matziol T, et al. Eur J Med Chem. 2026 Apr 4;311:118822.