TLR7 agonist 20

Chemical Structure : TLR7 agonist 20

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货号: PC-21750Not For Human Use, Lab Use Only.

TLR7 agonist 20 is a potent, selective TLR7 agonist with EC50 of 12 nM and 17 nM for hTLR and mTLR7 in cell-based reporter assay, respectively.

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生物&药学活性

TLR7 agonist 20 is a potent, selective TLR7 agonist with EC50 of 12 nM and 17 nM for hTLR and mTLR7 in cell-based reporter assay, respectively.
TLR7 agonist 20 displays no significant activity against TLR8 (EC50>5 uM).
TLR7 agonist 20 significantly induces secretion of cytokines IL-6, IL-1β, IL-10, TNFa, IFNa, and IP-10 in human and mouse whole blood. shows a significant secretion of IFNα and TNFα cytokines in pharmacokinetic and pharmacodynamic studies in mice.
TLR7 agonist 20 shows strong synergistic antitumor activity with complete tumor regression in 8/10 mice dosed using the intravenous route, when combined with aPD1.

物理化学性质&存储条件

分子量	483.62
分子式	C25H37N7O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-((5-amino-1-(2-methoxy-4-(((tetrahydro-2H-pyran-4-yl)amino)methyl)benzyl)-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino)hexan-1-ol

参考文献

1. Jayakodiarachchi N, et al. ACS Med Chem Lett. 2024 Jan 19;15(2):302-309.

TLR7 agonist 20

生物&药学活性

物理化学性质&存储条件

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TLR7 agonist 20

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