TLR7 agonist 17b

Chemical Structure : TLR7 agonist 17b

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货号: PC-21154Not For Human Use, Lab Use Only.

TLR7 agonist 17b is a potent, selective TLR7 agonist with EC50 of 18 nM in Ramos Blue reporter assays, >500-fold selective for TLR7 over TLR8.

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生物&药学活性

TLR7 agonist 17b is a potent, selective TLR7 agonist with EC50 of 18 nM in Ramos Blue reporter assays, >500-fold selective for TLR7 over TLR8.
TLR7 agonist 17b 35-fold more potent than R848.
TLR7 agonist 17b potently induces the release of IFNα and TNFα from hPBMCs at low-nanomolar concentrations.

物理化学性质&存储条件

分子量	516.65
分子式	C29H36N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	tert-Butyl (3-((4-((4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)methyl)phenyl)amino)-3-oxopropyl)carbamate

参考文献

1. Emma G. DeYoung, et al. ACS Medicinal Chemistry Letters 2023

TLR7 agonist 17b

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TLR7 agonist 17b

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