TLR7/8 antagonist 1

Chemical Structure : TLR7/8 antagonist 1

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货号: PC-25313Not For Human Use, Lab Use Only.

TLR7/8 antagonist 1 is a potent TLR7 and TLR8 antagonist with IC50 of 3.91 uM and 2.19 uM respectively, inhibits agonist induced TNFα, IFNγ, and IL-1β.

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100 mg		Get quote

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生物&药学活性

TLR7/8 antagonist 1 is a potent TLR7 and TLR8 antagonist with IC50 of 3.91 uM and 2.19 uM respectively, inhibits agonist induced TNFα, IFNγ, and IL-1β.

物理化学性质&存储条件

分子量	417.51
分子式	C24H27N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 4-amino-1-(4-(aminomethyl)benzyl)-2-isobutyl-1H-imidazo[4,5-c]quinoline-7-carboxylate

参考文献

1. Yang M, et al. Bioorg Med Chem Lett. 2022;59:128548.