TLR7-TLR8 agonist 31 |CAS:1413944-59-8 Probechem Biochemicals

Chemical Structure : TLR7-TLR8 agonist 31

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TLR7-TLR8 agonist 31

货号: PC-35315Not For Human Use, Lab Use Only.

TLR7 and 8 modulator 31 is a potent, orally active, dual TLR7 and 8 agonist with LEC values of 0.15 and 0.16 uM, respectively.

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100 mg		Get quote
250 mg		Get quote

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生物&药学活性

TLR7/TLR8 modulator 31 is a potent, orally active, dual TLR7 and 8 agonist with LEC values of 0.15 and 0.16 uM, respectively.
TLR7/TLR8 modulator 31 displays a good off-target profile (Aa1A, D1, 5HT2A IC50>10 µM; CYP 2D6 IC50=5.7 µM), also shows no significant activity against a panel of 80 receptors.
TLR7/TLR8 modulator 31 induces IFNα and pro-inflammatory cytokines at low dose in vivo, inhibits HBV replication indirectly, via cytokine induction and immune cells activation.
TLR7/TLR8 modulator 31 induces endogenous IFNα, an interferon stimulated gene response (ISGs), and also activation of myeloid dendritic cells and monocytes towards a TH1 phenotype in both mice and cynomolgus monkeys in vivo.

物理化学性质&存储条件

分子量	278.331
分子式	C14H19FN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-((2-Amino-8-fluoroquinazolin-4-yl)amino)hexan-1-ol

参考文献

1. Embrechts W, et al. J Med Chem. 2018 Jul 2. doi: 10.1021/acs.jmedchem.8b00643.