TLK1 inhibitor J54 | TLK1 inhibitor | Probechem Biochemicals

Chemical Structure : TLK1 inhibitor J54

CAS No.: 4734-59-2

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TLK1 inhibitor J54 (J3-54)

货号: PC-38651Not For Human Use, Lab Use Only.

TLK1 inhibitor J54 (J3-54) is a potent, small-molecule TLK1 inhibitor, induces apoptosis in AS PCa cells, suppresses growth of LNCaP xenografts combined with bicalutamide.

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5 mg	￥1280	In stock
10 mg	￥1880	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

TLK1 inhibitor J54 (J3-54) is a potent, small-molecule TLK1 inhibitor, induces apoptosis in AS PCa cells, suppresses growth of LNCaP xenografts combined with bicalutamide.
J54 showed much weaker binding to the DR2 than THD or risperidone.
J54 exhibits TLK1 inhibition with reduced pAKT S473 levels in a dose-dependent manner.

物理化学性质&存储条件

分子量	312.431
分子式	C18H20N2OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-(10H-phenothiazin-10-yl)ethyl)morpholine

参考文献

1. Vibha Singh, et al. iScience. 2020 Aug 20;23(9):101474.

2. Md Imtiaz Khalil, et al. Pathophysiology. 2021 Sep; 28(3): 339–354.

TLK1 inhibitor J54 (J3-54)

生物&药学活性

物理化学性质&存储条件

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TLK1 inhibitor J54 (J3-54)

生物&药学活性

物理化学性质&存储条件

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