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首页-新冠病毒相关-SARS-CoV-2 Inhibitors-TL1228
TL1228

Chemical Structure : TL1228

CAS No.: 2320491-70-9

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TL1228 (TL-1228)

货号: PC-23213Not For Human Use, Lab Use Only.

TL1228 is a small molecule inhibitor of SARS-CoV-2 and its target cells, blocking the recognition of the GRP78 cellular receptor by the viral Spike protein, also is a selective inhibitor of the dihydrofolate reductase (DHFR) type B1.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

TL1228 is a small molecule inhibitor of SARS-CoV-2 and its target cells, blocking the recognition of the GRP78 cellular receptor by the viral Spike protein, also is a selective inhibitor of the dihydrofolate reductase (DHFR) type B1.
TL1228 (30 and 40 µM) hampers the VSV_Pseudo SARS-CoV-2 S Omicron BA.4/5 and BQ1.1 variants in Vero E6 cells.
TL1228 hinders the infection by VSV_Pseudo SARS-CoV-2 S Omicron BQ1.1 and XBB.1.5 in Calu-3 cells.
TL1228 affects VSV_Pseudo SARS-CoV-2 S Omicron XBB.1.5 infection.

物理化学性质&存储条件

分子量 564.55
分子式 C31H24N4O7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,2'-(((2-hydroxypropane-1,3-diyl)bis(oxy))bis(3,1-phenylene))bis(1H-benzo[d]imidazole-5-carboxylic acid)

参考文献

1. Bastien D, J Med Chem. 2012;55:3182–92.

2. Michela Murdocca, et al. Biol Direct. 2024 Oct 16;19(1):93.

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