TL02-59 |CAS:1315330-17-6 Probechem Biochemicals

Chemical Structure : TL02-59

CAS No.: 1315330-17-6

加入收藏

TL02-59 (TL 02-59)

货号: PC-35102Not For Human Use, Lab Use Only.

TL02-59 is a potent, selective, orally available inhibitor of Src-family kinase Fgr IC50 of 0.03 nM, also inhibits Lyn and Hck with IC50 of 0.1 and 160 nM, respectively.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4780	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

TL02-59 is a potent, selective, orally available inhibitor of Src-family kinase Fgr IC50 of 0.03 nM, also inhibits Lyn and Hck with IC50 of 0.1 and 160 nM, respectively.
TL02-59 inhibits Syk, Fes, Flt3-WT and Flt3-ITD with IC50 of 470, 290, 633 and 440 nM, inhibits MV4-11 AML cell growth with IC50 of <1 nM.
TL02-59 completely eliminates leukemic cells from the spleen and peripheral blood while significantly reducing bone marrow engraftment at 10 mg/kg in mouse xenograft model of AML.

物理化学性质&存储条件

分子量	609.65
分子式	C32H34F3N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((6,7-dimethoxyquinazolin-4-yl)oxy)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide

参考文献

1. Weir MC, et al. ACS Chem Biol. 2018 May 15. doi: 10.1021/acschembio.8b00154.

TL02-59 (TL 02-59)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

TL02-59 (TL 02-59)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.