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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-TKDC
TKDC

Chemical Structure : TKDC

CAS No.: 425666-42-8

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TKDC

货号: PC-60942Not For Human Use, Lab Use Only.

TKDC is a small molecule allosteric inhibitor of TREK channels with IC50 of 4.9, 5.2 and 65.9 uM for TREK-1, TREK-2 and TRAAK, respectively.

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25 mg ￥3980 In stock
50 mg ￥5880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TKDC is a small molecule allosteric inhibitor of TREK channels with IC50 of 4.9, 5.2 and 65.9 uM for TREK-1, TREK-2 and TRAAK, respectively.
TKDC maintains potency for mutant TREK-1 channels with IC50 of 2.4, 2.4 and 2.2 uM for T79A TREK-1, Q83A TREK-1 and Q105A TREK-1, respectively.
TKDC decreases immobility and induces antidepressant-like effects in mice.

物理化学性质&存储条件

分子量 378.871
分子式 C18H19ClN2O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-chlorophenyl)-N-(2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl)methanesulfonamide

参考文献

1. Luo Q, et al. Nat Commun. 2017 Aug 29;8(1):378.

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