TKB272 | SARS-CoV-2 Mpro inhibitor | Probechem Biochemicals

Chemical Structure : TKB272

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TKB272 (TBK-272)

货号: PC-23891Not For Human Use, Lab Use Only.

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250 mg		Get quote

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生物&药学活性

TKB272 is a potent, selective inhibitor of SARS-CoV-2 main protease (Mpro) with IC50 of 0.7 nM, effectively blocks the infectivity and replication of SARS-CoV-2 strains (SARS-CoV-2 WK-521, EC50=7.0 nM, VeroE6 cell).
TKB272 inhibits Omicron variants such as SARS-CoV-2XBB1.5 and SARS-CoV-2EG.5.1.
TKB272 blockes SARS-CoV-2XBB1.5 replication without ritonavir in B6.Cg-Tg(K18-hACE2)2-Prlmn/J-transgenic mice. TKB272 shows no apparent genotoxicity as tested in the micro-Ames test.

物理化学性质&存储条件

分子量	653.69
分子式	C30H35F4N5O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2S,5S)-3-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-N-((S)-1-(5-fluorobenzo[d]thiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide

参考文献

1. Higashi-Kuwata N, et al. PNAS Nexus. 2025 Jan 7;4(1):pgae578.

TKB272 (TBK-272)

生物&药学活性

物理化学性质&存储条件

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TKB272 (TBK-272)

生物&药学活性

物理化学性质&存储条件

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