TKB248 | SARS-CoV-2 Mpro inhibitor | Probechem Biochemicals

Chemical Structure : TKB248

加入收藏

TKB248 (TKB-248)

货号: PC-49865Not For Human Use, Lab Use Only.

TKB248 (TKB-248) is a potent, specific SARS-CoV-2 Mpro inhibitor with IC50 of 74 nM, exhibits highly potent anti-SARS-CoV-2 activity with EC50 and EC95 values of 0.22 and 0.87 µM, respectively.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

TKB248 (TKB-248) is a potent, specific SARS-CoV-2 Mpro inhibitor with IC50 of 74 nM, exhibits highly potent anti-SARS-CoV-2 activity with EC50 and EC95 values of 0.22 and 0.87 µM, respectively.
TKB248 does not inhibits human cysteine enzymes, cathepsin L and calpain.
TKB248 demonstrates comparably active against a variety of SARS-CoV-2 variants including alpha, beta, gamma, delta, kappa, and omicron species (EC50=70-430 nM).
TKB248 exerts potent anti-SARS-CoV-2 activity in VeroE6 cells in the presence of CP100356 with EC50 of 25 nM.
TKB248 (120 mg/ kg BID, i.p.) exhibits significantly lower virus titer in human ACE2-knocked-in mice following SARS-CoV-2 exposure.

物理化学性质&存储条件

分子量	669.75
分子式	C30H35F4N5O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,2,2-trifluoro-N-((S)-1-((1R,2S,5S)-2-(((S)-1-(4-fluorobenzo[d]thiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)carbamothioyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-3-yl)-3,3-dimethyl-1-oxobutan-2-yl)acetamide

参考文献

1. Higashi-Kuwata N, et al. Nat Commun. 2023 Feb 25;14(1):1076.

TKB248 (TKB-248)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

TKB248 (TKB-248)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.