TKB245 | SARS-CoV-2 Mpro inhibitor | Probechem Biochemicals

Chemical Structure : TKB245

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TKB245 (TKB-245)

货号: PC-49864Not For Human Use, Lab Use Only.

TKB245 (TKB-245) is a potent, specific SARS-CoV-2 Mpro inhibitor with IC50 of 7 nM, exhibits highly potent anti-SARS-CoV-2 activity with EC50 and EC95 values of 0.03 and 0.53 µM, respectively.

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生物&药学活性

TKB245 (TKB-245) is a potent, specific SARS-CoV-2 Mpro inhibitor with IC50 of 7 nM, exhibits highly potent anti-SARS-CoV-2 activity with EC50 and EC95 values of 0.03 and 0.53 µM, respectively.
TKB245 does not inhibits human cysteine enzymes, cathepsin L and calpain.
TKB245 demonstrates comparably active against a variety of SARS-CoV-2 variants including alpha, beta, gamma, delta, kappa, and omicron species (EC50=14-56 nM).
TKB245 exerts potent activity against SARS-CoV-2TWK521 with EC50 values of 0.021 and 0.0027 µM, respectively in HeLa-ACE2-TMPRSS2 and A549-ACE2-TMPRSS2 cells.
TKB245 exhibits significantly more potent activity than the two existing anti-SARS-CoV-2 drugs: molnupiravir and nirmatrelvir.

物理化学性质&存储条件

分子量	653.69
分子式	C30H35F4N5O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2S,5S)-3-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-N-((S)-1-(4-fluorobenzo[d]thiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide

参考文献

1. Higashi-Kuwata N, et al. Nat Commun. 2023 Feb 25;14(1):1076.

TKB245 (TKB-245)

生物&药学活性

物理化学性质&存储条件

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TKB245 (TKB-245)

生物&药学活性

物理化学性质&存储条件

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