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首页-小分子抑制剂&激动剂-Others-Other Targets-TK216
TK216

Chemical Structure : TK216

CAS No.: 1903783-48-1

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TK216 (TK 216, TK-216)

货号: PC-61994Not For Human Use, Lab Use Only.

TK216 is a first in class, small molecule that directly binds EWS-FLI1 inhibiting the biological activity of ETS-family transcription factor oncoproteins and is currently under clinical investigation against Ewing sarcoma..

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5 mg ￥980 In stock
10 mg ￥1580 In stock
25 mg ￥2580 In stock
50 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TK216 is a first in class, small molecule that directly binds EWS-FLI1 inhibiting the biological activity of ETS-family transcription factor oncoproteins and is currently under clinical investigation against Ewing sarcoma.
TK216 acts as an microtubule destabilizing agent, exhibits anti-cancer activity against cancer cell lines and xenografts that do not express EWSR1-FLI1.

物理化学性质&存储条件

分子量 376.233
分子式 C19H15Cl2NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4,7-dichloro-3-(2-(4-cyclopropylphenyl)-2-oxoethyl)-3-hydroxyindolin-2-one

参考文献

1, Filippo Spriano, et al. Clin Cancer Res. 2019 Aug 15;25(16):5167-5176.

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