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首页-小分子抑制剂&激动剂-Epigenetics-Bromodomain-TK-285
TK-285

Chemical Structure : TK-285

CAS No.:

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TK-285 (TK285)

货号: PC-26533Not For Human Use, Lab Use Only.

TK-285 is a potent inhibitor of TSLP production, binds to the BD1 domain of BRD4 with Kd of 190 nM, inhibits TSLP production by preventing BRD4 from binding to the TSLP promoter region.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

TK-285 is a potent inhibitor of TSLP production, binds to the BD1 domain of BRD4 with Kd of 190 nM, inhibits TSLP production by preventing BRD4 from binding to the TSLP promoter region.

物理化学性质&存储条件

分子量 474.56
分子式 C28H30N2O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-N-(4-ethoxy-5-methoxy-2-(3-(2-(pyridin-3-ylmethoxy)phenyl)acryloyl)phenethyl)acetamide

参考文献

1. Hiroyuki Yamakoshi, et al. J Med Chem. 2026 Apr 9;69(7):8388-8416.

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