TJ0113 | Mitophagy inducer, PINK1-Parkin activator | Probechem Biochemicals

Chemical Structure : TJ0113

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TJ0113 (TJ-0113)

货号: PC-27707Not For Human Use, Lab Use Only.

TJ0113 is a UMI-77 derivative and mitophagy inducer, targets Mcl-1 binding to LC3A, selectively activates the PINK1-Parkin signaling cascade and enhances mitophagy flux in vitro and in vivo.

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生物&药学活性

TJ0113 is a UMI-77 derivative and mitophagy inducer, targets Mcl-1 binding to LC3A, selectively activates the PINK1-Parkin signaling cascade and enhances mitophagy flux in vitro and in vivo.
TJ0113 effectively induces the production of mitochondrial autophagosomes (APP) in hepatocytes.
TJ0113 induces mitophagy and ameliorates mitochondrial damage in hepatocytes of MASH mice.
TJ0113-induced mitophagy is dependent on the PINK1/Parkin pathway.
TJ0113 reduced body weight, liver weight, insulin resistance, glucose tolerance and liver function changes in MASH mice, reduces serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in HFD-fed mice.
TJ0113 (3 mg/kg and 7 mg/kg, gavage) attenuates liver fibrosis (LF) in MASH mice.
TJ0113 inhibits the activation of NLRP3 inflammatory vesicles and ameliorates the inflammatory response in MASH mice.
TJ0113 induces autophagy in LX-2 cells.
TJ0113 (1 uM) inhibits TGF-β1 (10 ng/mL)-induced fibrotic response through activation of mitophagy in LX-2 cells, significantly reduces ROS production in LX-2 cells.

物理化学性质&存储条件

分子量	506.32
分子式	C18H13BrNNaO6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	sodium 2-((4-((4-bromophenyl)sulfonamido)-1-hydroxynaphthalen-2-yl)sulfinyl)acetate

参考文献

1. Huang CL, et al. Int Immunopharmacol. 2025 May 27;156:114678.

2. Huang C, et al. Redox Biol. 2025 Jun;83:103654.

3. Tian Y, et al. Toxicol Appl Pharmacol. 2025 Dec;505:117565.

TJ0113 (TJ-0113)

生物&药学活性

物理化学性质&存储条件

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TJ0113 (TJ-0113)

生物&药学活性

物理化学性质&存储条件

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