TIPTP | p22phox inhibitor | Probechem Biochemicals

Chemical Structure : TIPTP

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TIPTP (p22phox inhibitor TIPTP)

货号: PC-49019Not For Human Use, Lab Use Only.

TIPTP is a highly potent and selective inhibitor of p22phox, inhibits the p22phox-Rubicon interaction with IC50 of 0.1 uM, and suppresses ROS-mediated inflammation.

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生物&药学活性

TIPTP is a highly potent and selective inhibitor of p22phox, inhibits the p22phox-Rubicon interaction with IC50 of 0.1 uM, and suppresses ROS-mediated inflammation.
TIPTP showed considerably improved potency (100-fold) and selectivity than the previously reported N8 peptide-mimetic small molecule.
TIPTP inhibits NLRP3 inflammasomes induced by ROS in vivo.
TIPTP showed enhance therapeutic effects ex vivo on monocytes from healthy individuals and synovial fluid cells from RA patients, and in mouse models for rheumatoid arthritis
(RA).

物理化学性质&存储条件

分子量	437.441
分子式	C19H18F3N5O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-(3-(4,5,6,7-tetrahydro-2H-indazol-2-yl)phenoxy)-N-(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)propanamide

参考文献

1. Kim YR, et al. Sci Rep. 2020 Mar 12;10(1):4570.

TIPTP (p22phox inhibitor TIPTP)

生物&药学活性

物理化学性质&存储条件

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TIPTP (p22phox inhibitor TIPTP)

生物&药学活性

物理化学性质&存储条件

参考文献

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