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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-PPAR-TIPP-401
TIPP-401

Chemical Structure : TIPP-401

CAS No.: 876296-16-1

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TIPP-401 (TIPP401)

货号: PC-23875Not For Human Use, Lab Use Only.

TIPP-401 is a potent, selective PPARα/δ agonist with EC50 of 10/12 nM, >150-fold selective PPARγ.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

TIPP-401 is a potent, selective PPARα/δ agonist with EC50 of 10/12 nM, >150-fold selective PPARγ.
TIPP-401 is specific for PPARα and PPARδ, does not significantly activate VDR, PPARγ, LXRα, RARα or RXRα at concentrations up to 1 μM.
TIPP-401 possesses potent PPARα/δ transactivation activity with high selectivity over PPARγ.

物理化学性质&存储条件

分子量 427.40
分子式 C21H21F4NO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2s)-2-{3-[({[2-Fluoro-4-(Trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-Methoxybenzyl}butanoic Acid

参考文献

1. Kasuga J, et al. Bioorg Med Chem. 2006 Dec 15;14(24):8405-14.

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