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首页-小分子抑制剂&激动剂-Others-AP2-associated Kinase 1 (AAK1)-TIM-098a
TIM-098a

Chemical Structure : TIM-098a

CAS No.:

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TIM-098a (TIM098a)

货号: PC-22031Not For Human Use, Lab Use Only.

TIM-098a is a potent, selective AP2-associated protein kinase 1 (AAK1) with IC50 of 0.24 uM, inhibits AAK1 activity in transfected cultured cells with IC50 of 0.87 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

TIM-098a is a potent, selective AP2-associated protein kinase 1 (AAK1) with IC50 of 0.24 uM, inhibits AAK1 activity in transfected cultured cells with IC50 of 0.87 uM.
TIM-098a displays 4–30-fold selectivity over other NAKs, including GAK, BIKE, and STK16.
TIM-098a (10 uM) suppresses the AAK1-regulated clathrin-dependent endocytosis in HeLa cells.

物理化学性质&存储条件

分子量 301.31
分子式 C18H11N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

11-amino-2-hydroxy-7H-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinolin-7-one

参考文献

1. Akari Yoshida, et al. Sci Rep. 2024 Mar 20;14(1):6723.

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