TIM-063 | CaMKK inhibitor | Probechem Biochemicals

Chemical Structure : TIM-063

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TIM-063 (TIM063, TIM 063)

货号: PC-72949Not For Human Use, Lab Use Only.

TIM-063 (TIM063) is a potent, selective, ATP-competitive CaMKK inhibitor with Ki of 0.35/0.2 uM for CaMKKα and CaMKKβ, respectively.

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生物&药学活性

TIM-063 (TIM063) is a potent, selective, ATP-competitive CaMKK inhibitor with Ki of 0.35/0.2 uM for CaMKKα and CaMKKβ, respectively.
TIM-063 directly targets the catalytic domain of CaMKK, similar to STO-609.
TIM-063 suppressed the ionomycin-induced phosphorylation of exogenously expressed CaMKI, CaMKIV, and endogenous AMPKα in HeLa cells with an IC50 of 0.3 uM.
TIM-063 suppressed CaMKK isoform-mediated CaMKIV phosphorylation in transfected COS-7 cells.
TIM-063 displayed cell permeability and the ability to inhibit CaMKK activity in cells.
TIM-063 is a useful chemical probe for the precise analysis of CaMKK-mediated signaling pathways.

物理化学性质&存储条件

分子量	331.287
分子式	C18H9N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-hydroxy-3-nitro-7H-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinolin-7-one

参考文献

1. Ohtsuka S, et al. Biochemistry. 2020 May 5;59(17):1701-1710.

2. Satomi Ohtsuka, et al. Biochemistry, March 11, 2022.

3. Toshio Kitazawa, et al. Am J Physiol Cell Physiol. 2021 Sep 1;321(3):C549-C558.

TIM-063 (TIM063, TIM 063)

生物&药学活性

物理化学性质&存储条件

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TIM-063 (TIM063, TIM 063)

生物&药学活性

物理化学性质&存储条件

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