THRX-144644 | ALK5 inhibitor | Probechem Biochemicals

Chemical Structure : THRX-144644

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THRX-144644 (THRX144644)

货号: PC-38197Not For Human Use, Lab Use Only.

THRX-144644 (THRX144644) is a potent, lung-selective ALK5 inhibitor with IC50 of 0.14 nM, inhibits p-SMAD3 in a BEAS2B cell line with IC50 of 23 nM.

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生物&药学活性

THRX-144644 (THRX144644) is a potent, lung-selective ALK5 inhibitor with IC50 of 0.14 nM, inhibits p-SMAD3 in a BEAS2B cell line with IC50 of 23 nM。
THRX-144644 displays high selectivity in a broad secondary pharmacology panel with exception of e Lymphocyte CellSpecific Protein-Tyrosine Kinase (LCK, IC50=140 nM).
THRX-144644 demonstrated favorable TGFβ pathway pharmacodynamic inhibition in lung while minimizing key systemic toxicities.

物理化学性质&存储条件

分子量	512.006
分子式	C26H28ClF2N7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(3-(5-chloro-2,4-difluorophenyl)-1H-pyrazol-4-yl)-N-(2-(4-isopropylpiperazin-1-yl)ethyl)-1,5-naphthyridin-3-amine

参考文献

1. Jonathan Maher, et al. Toxicol Appl Pharmacol. 2022 Feb 2;115905.

THRX-144644 (THRX144644)

生物&药学活性

物理化学性质&存储条件

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THRX-144644 (THRX144644)

生物&药学活性

物理化学性质&存储条件

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