THPN

Chemical Structure : THPN

CAS No.: 100079-26-3

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货号: PC-60381Not For Human Use, Lab Use Only.

THPN is a potent specific agonist of nuclear receptor TR3 (Nur77) with Kd of 270 nM for Nur77 LDB, induces melanoma autophagy through a mitochondrial signaling pathway.

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10 mg	￥3980	In stock
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生物&药学活性

THPN is a potent specific agonist of nuclear receptor TR3 (Nur77) with Kd of 270 nM for Nur77 LDB, induces melanoma autophagy through a mitochondrial signaling pathway.
THPN binds TR3 to facilitate the interaction with Nix, induces TR3 localization to MIM.
THPN significantly represses tumor growth in xenograft mouse model.
THPN is a chemical probe to study TR3-mediated signal transduction pathway.

物理化学性质&存储条件

分子量	266.34
分子式	C15H22O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3,4,5-Trihydroxyphenyl)nonan-1-one

参考文献

1. Wang WJ, et al. Chem Biol. 2015 Aug 20;22(8):1040-51.

2. Wang WJ, et al. Nat Chem Biol. 2014 Feb;10(2):133-40.

THPN

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