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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Antifolate-TH9028
TH9028

Chemical Structure : TH9028

CAS No.: 2379556-15-5

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TH9028 (TH-9028)

货号: PC-72939Not For Human Use, Lab Use Only.

TH9028 (TH-9028) is a potent and selective inhibitor of folate metabolism enzyme MTHFD2 with IC50 of 11 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    TH9028 (TH-9028) is a potent and selective inhibitor of folate metabolism enzyme MTHFD2 with IC50 of 11 nM.
    TH9028demonstrated efficacy on HL-60 cell viability with EC50 of 11 nM.
    TH9028 potently inhibits related MTHFD proteins MTHFD2L and MTHFD1-(DC) with IC50 of 47 and 16 nM, respectively.

    物理化学性质&存储条件

    分子量 458.399
    分子式 C16H18N12O5
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-2-(5-(3-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)ureido)picolinamido)-4-(1H-tetrazol-5-yl)butanoic acid

    参考文献

    1. Nadilly Bonagas, et al. Nat Cancer. 2022 Feb;3(2):156-172.

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