TH8535 | OGG1 inhibitor | Probechem Biochemicals

Chemical Structure : TH8535

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TH8535 (TH-8535)

货号: PC-49645Not For Human Use, Lab Use Only.

TH8535 (TH-8535) is a potent, selective inhibitor of 8-oxo Guanine DNA Glycosylase 1 (OGG1) with IC50 of 0.2 uM.

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生物&药学活性

TH8535 (TH-8535) is a potent, selective inhibitor of 8-oxo Guanine DNA Glycosylase 1 (OGG1) with IC50 of 0.2 uM.
TH8535 displays high selectivity against a number of DNA glycosylases and base excision repair enzymes (IC50>100 uM).
TH8535 caused a significant loss of viability in a number of cancer cells at μM potency, while being better tolerated in non-transformed cell lines.

物理化学性质&存储条件

分子量	459.34
分子式	C21H23BrN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-bromo-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-(3-methoxy-4-methylphenyl)piperidine-1-carboxamide

参考文献

1. Olov Wallner, et al. ChemMedChem. 2023 Jan 3;18(1):e202200310.

TH8535 (TH-8535)

生物&药学活性

物理化学性质&存储条件

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TH8535 (TH-8535)

生物&药学活性

物理化学性质&存储条件

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