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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Antifolate-TH7299
TH7299

Chemical Structure : TH7299

CAS No.: 1415648-20-2

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TH7299 (TH 7299)

货号: PC-47090Not For Human Use, Lab Use Only.

TH7299 is a potent mitochondrial inhibitor of mitochondrial MTHFD2L with IC50 of 274 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    TH7299 is a potent mitochondrial inhibitor of mitochondrial MTHFD2L with IC50 of 274 nM.
    TH7299 is a highly selective towards MTHFD2 (IC50=254 nM) over other enzymes involved in 1C-metabolism (i.e. SHMT1/2, TS and DHFR).
    TH7299 is a potent inhibitor of the structurally related MTHFD2 isoforms MTHFD2L (IC50: 126 nM) and MTHFD1-DC (IC50: 89 nM).

    物理化学性质&存储条件

    分子量 433.381
    分子式 C17H19N7O7
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (4-(3-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)ureido)benzoyl)-L-glutamic acid

    参考文献

    1. Nadilly Bonagas, et al. Nat Cancer. 2022 Feb;3(2):156-172.

    2. Benramdane S, et al. ChemMedChem. 2022 Jun 27:e202200097.

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