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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA Repair Protein -TH588 hydrochloride
TH588 hydrochloride

Chemical Structure : TH588 hydrochloride

CAS No.: 1640282-30-9

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TH588 hydrochloride (TH-588 hydrochloride)

货号: PC-43227Not For Human Use, Lab Use Only.

TH588 hydrochloride is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 5 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TH588 hydrochloride is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 5 nM.
TH588 hydrochloride shows no relevant inhibition for MTH2,NUDT5, NUDT12,NUDT14,NUDT16 and other proteinswith known nucleoside triphosphate pyrophosphatase activity.
TH588 hydrochloride causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.

物理化学性质&存储条件

分子量 331.6281
分子式 C13H13Cl3N4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,4-Pyrimidinediamine, N4-cyclopropyl-6-(2,3-dichlorophenyl)-, hydrochloride (1:1)

参考文献

1. Gad H, et al. Nature. 2014 Apr 10;508(7495):215-21.

2. Wang M, et al. Sci Rep. 2017 Jan 11;7:40557.

3. Warpman Berglund U, et al. Ann Oncol. 2016 Dec;27(12):2275-2283.

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