TH1834 dihydrochloride |CAS:2108830-09-5 Probechem Biochemicals

Chemical Structure : TH1834 dihydrochloride

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TH1834 dihydrochloride (TH-1834;TH 1834)

货号: PC-60499Not For Human Use, Lab Use Only.

TH1834 dihydrochloride (TH-1834, TH 1834) is a novel potent specific histone acetyltransferase Tip60 inhibitor.

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生物&药学活性

TH1834 dihydrochloride (TH-1834, TH 1834) is a novel potent specific histone acetyltransferase Tip60 inhibitor.
TH1834 induces apoptosis in breast cancer cell lines with more cytotoxicity than staurosporine.
TH1834 increases the γH2AX foci in the cancer cell lines PC-3 and DU-145 combined with IR.
TH1834 induces apoptosis and increases unrepaired DNA damage in breast cancer cells.

物理化学性质&存储条件

分子量	641.638
分子式	C33H42Cl2N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(5-(4-((phenethyl(4-(4-(pyrrolidin-1-ylmethyl)phenoxy)butyl)amino)methyl)phenyl)-2H-tetrazol-2-yl)acetic acid dihydrochloride

参考文献

1. Gao C, et al. Sci Rep. 2014 Jun 20;4:5372.

TH1834 dihydrochloride (TH-1834;TH 1834)

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物理化学性质&存储条件

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TH1834 dihydrochloride (TH-1834;TH 1834)

生物&药学活性

物理化学性质&存储条件

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