TH10785 | OGG1 activator | Probechem Biochemicals

Chemical Structure : TH10785

CAS No.: 1002801-51-5

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TH10785 (TH 10785)

货号: PC-47083Not For Human Use, Lab Use Only.

TH10785 is a small-molecule activator of 8-oxoguanine (8-oxoG) DNA glycosylase 1 (OGG1), increases the enzyme activity 10-fold, TH10785 increases OGG1 recruitment to and repair of oxidative DNA damage in cells.

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生物&药学活性

TH10785 is a small-molecule activator of 8-oxoguanine (8-oxoG) DNA glycosylase 1 (OGG1), increases the enzyme activity 10-fold, TH10785 increases OGG1 recruitment to and repair of oxidative DNA damage in cells.
TH10785 interacts with the phenylalanine-319 and glycine-42 amino acids of OGG1, controls the catalytic activity mediated by a nitrogen base within its molecular structure.
TH10785 alters the repair process, which no longer requires APE1 but instead is dependent on polynucleotide kinase phosphatase (PNKP1) activity.

物理化学性质&存储条件

分子量	267.376
分子式	C17H21N3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-cyclohexyl-2-cyclopropylquinazolin-4-amine

参考文献

1. Maurice Michel, et al. Science. 2022 Jun 24;376(6600):1471-1476.

TH10785 (TH 10785)

生物&药学活性

物理化学性质&存储条件

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TH10785 (TH 10785)

生物&药学活性

物理化学性质&存储条件

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