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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Toll-like Receptor (TLR)-TH1027
TH1027

Chemical Structure : TH1027

CAS No.: 2552120-13-3

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TH1027 (TH-1027)

货号: PC-26537Not For Human Use, Lab Use Only.

TH1027 is a highly potent and specific inhibitor of TLR8, dose-dependently inhibited R848-or ssRNA06-induced TLR8 activation with IC50 of 30 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

TH1027 is a highly potent and specific inhibitor of TLR8, dose-dependently inhibited R848-or ssRNA06-induced TLR8 activation with IC50 of 30 nM.
TH1027 binds to human TLR8 (hTLR8) with Kd of 225 nM.
TH1027 inhibits TLR8-mediated signaling without affecting other TLRs including TLR1/2, TLR2/6, TLR3, TLR4, TLR5, TLR7, and TLR9.
TH1027 (1 uM) completely abolished the elevation of TNF-α and IL-8 mRNA levels induced by R848 in HEK-Blue TLR8 cells.

物理化学性质&存储条件

分子量 291.41
分子式 C15H21N3OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(5-(Methylthio)-4-(3,4,5-trimethylphenyl)-4H-1,2,4-triazol-3-yl)propan-1-ol

参考文献

1. Shuangshuang Jiang, et al. J Med Chem. 2020 Apr 23;63(8):4117-4132.

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