TH1020 | TLR5 antagonist | Probechem Biochemicals

Chemical Structure : TH1020

CAS No.: 1841460-82-9

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TH1020 (TH-1020, TH 1020)

货号: PC-21372Not For Human Use, Lab Use Only.

TH1020 is a potent, selective antagonist of TLR5/flagellin protein-protein interaction with IC50 of 0.85 uM.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg		Get quote

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生物&药学活性

TH1020 is a potent, selective antagonist of TLR5/flagellin protein-protein interaction with IC50 of 0.85 uM.
TH1020 exhibits nearly negligible inhibition of TLR2, TLT4, TLR7 and TLR8 at 0.78 uM, and weak inhibition of TLR3.
TH1020 represses the expression of downstream TNF-α signaling pathways mediated by the TLR5/flagellin complex formation.
TH1020 almost completely abolishes the TLR5-mediated TNF-α secretion at 0.37 uM in primary human peripheral blood mononuclear cells (PBMCs).

物理化学性质&存储条件

分子量	453.54
分子式	C23H15N7S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((4-Benzyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)pyrido[3',2':4,5]thieno[3,2-d]pyrimidine

参考文献

1. Yan L, et al. ChemMedChem. 2016 Apr 19;11(8):822-6.

2. Kamada H, et al. Sci Rep. 2023 Oct 28;13(1):18490.

TH1020 (TH-1020, TH 1020)

生物&药学活性

物理化学性质&存储条件

参考文献

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TH1020 (TH-1020, TH 1020)

生物&药学活性

物理化学性质&存储条件

参考文献

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