TH-407b | TLR7 inhibitor | Probechem Biochemicals

Chemical Structure : TH-407b

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TH-407b (TH407b)

货号: PC-23645Not For Human Use, Lab Use Only.

TH-407b is a potent and selective TLR7 inhibitor, dose-dependently inhibits R848-induced TLR7 activation with IC50 of 0.23 uM in HEK-Blue hTLR7 cells.

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生物&药学活性

TH-407b is a potent and selective TLR7 inhibitor, dose-dependently inhibits R848-induced TLR7 activation with IC50 of 0.23 uM in HEK-Blue hTLR7 cells.
TH-407b binds to TLR7 (ITC KD=5.1 uM) and induces receptors dimerization, stabilizes the inactivated dimeric state.
TH-407b inhibits TLR7 signaling pathway and TLR7-mediated cytokine production.
TH-407b not only effectively inhibits TLR7-mediated pro-inflammatory signaling in a variety of cultured cell lines but also demonstrates potent inflammation suppressing activities in primary peripheral blood mononuclear cells (PBMCs) derived from systemic lupus erythematosus (SLE) patients.
TH-407b shows prominent efficacy in vivo, improves survival rate and ameliorates symptoms of SLE model mice.

物理化学性质&存储条件

分子量	434.49
分子式	C24H26N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Tricyclo[3.3.1.13,7]decan-2-one, 5-[[4-(8-nitro-5-quinolinyl)-1-piperazinyl]carbonyl]-

参考文献

1. Wang M, et al. Acta Pharm Sin B. 2024 Nov;14(11):4899-4913.

TH-407b (TH407b)

生物&药学活性

物理化学性质&存储条件

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TH-407b (TH407b)

生物&药学活性

物理化学性质&存储条件

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