TH-287 hydrochloride | MTH1 inhibitor | Probechem Biochemicals

Chemical Structure : TH-287 hydrochloride

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TH-287 hydrochloride (TH287 hydrochloride)

货号: PC-45105Not For Human Use, Lab Use Only.

TH-287 hydrochloride is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 0.8 nM.

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生物&药学活性

TH-287 hydrochloride is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 0.8 nM.
TH-287 shows no relevant inhibition for MTH2,NUDT5, NUDT12,NUDT14,NUDT16 and other proteinswith known nucleoside triphosphate pyrophosphatase activity.
TH-287 causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.

物理化学性质&存储条件

分子量	305.5909
分子式	C11H11Cl3N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,4-Pyrimidinediamine, 6-(2,3-dichlorophenyl)-N4-methyl-, hydrochloride (1:1)

参考文献

1. Gad H, et al. Nature. 2014 Apr 10;508(7495):215-21.

2. Wang M, et al. Sci Rep. 2017 Jan 11;7:40557.

3. Kawamura T, et al. Sci Rep. 2016 May 23;6:26521.

TH-287 hydrochloride (TH287 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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TH-287 hydrochloride (TH287 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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