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首页-小分子抑制剂&激动剂-GPCR-TGR5 (GPCR19, GPR131, GPBAR1)-TGR5 agonist 45h
TGR5 agonist 45h

Chemical Structure : TGR5 agonist 45h

CAS No.: 1595145-44-0

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TGR5 agonist 45h

货号: PC-20448Not For Human Use, Lab Use Only.

TGR5 agonist 45h is a potent, selective and orally bioavailable TGR5 (GPBAR1) agonist with cAMP EC50 of 15 and 1 nM for hTGR5 and mTGR5, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    TGR5 agonist 45h is a potent, selective and orally bioavailable TGR5 (GPBAR1) agonist with cAMP EC50 of 15 and 1 nM for hTGR5 and mTGR5, respectively.

    物理化学性质&存储条件

    分子量 577.61
    分子式 C31H30F3N5O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    trans-4-[4-[6-[(2S)-2-[[[2-(4-Cyanophenyl)ethyl]amino]carbonyl]-1-azetidinyl]-2-(trifluoromethyl)-4-pyrimidinyl]phenyl]cyclohexanecarboxylic acid

    参考文献

    1. Dean P Phillips, et al. J Med Chem. 2014 Apr 24;57(8):3263-82.

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