TGP-29b-066 | miR-29b inhibitor | Probechem Biochemicals

Chemical Structure : TGP-29b-066

CAS No.: 349429-86-3

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TGP-29b-066 (Targapremir-29b-066)

货号: PC-20105Not For Human Use, Lab Use Only.

TGP-29b-066 (Targapremir-29b-066) is a specfic small-molecule miR-29b inhibitor that targets miR29b hairpin precursor (pre-miR-29b), selectivity and effectively decreases miR-29b expression levels in C2C12 myoblast, attenuates muscle atrophy in vitro and in vivo.

规格	价格	库存
5 mg	￥2780	In stock
10 mg	￥4580	In stock
25 mg	￥7880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

TGP-29b-066 (Targapremir-29b-066) is a specfic small-molecule miR-29b inhibitor that targets miR29b hairpin precursor (pre-miR-29b), selectivity and effectively decreases miR-29b expression levels in C2C12 myoblast, attenuates muscle atrophy in vitro and in vivo.
TGP-29b-066 specifically inhibits mature miR-29b generation in C2C12 myotubes (24 h) with IC50 of 30 uM.
TGP-29b-066 significantly attenuates muscle atrophy induced by Ang II in C2C12 myotubes, also increases the diameter of myotube and decreases Atrogin-1 and MuRF-1 expression levels, while does not affect C2C12 differentiation.
TGP-29b-066 ameliorates muscle atrophy in Ang II-induced muscle atrophy mice model, reduces the elevation of Atrogin-1 and MuRF-1.
TGP-29b-066 also attenuates the reduction of the cross-sectional area of myofibers, reduces cell apoptosis and autophag in Ang II-treated mice.
TGP-29b-066 represses miR-29b generation via interfering with the stability of pre-miR-29b, directly binds to pre-miR-29b-1/2, which in turn reduced pre-miR-29b-1/2 stability.
TGP-29b-066 also shows a longer inhibitory effect than antisense oligodeoxynucleotides of miR-29b (ASO-miR-29b).

物理化学性质&存储条件

分子量	246.69
分子式	C13H11ClN2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-chlorophenyl)-N-(pyridin-2-yl)acetamide

参考文献

1. Liu Q, et al. Mol Ther Nucleic Acids. 2023 Feb 4;31:527-540.

TGP-29b-066 (Targapremir-29b-066)

生物&药学活性

物理化学性质&存储条件

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TGP-29b-066 (Targapremir-29b-066)

生物&药学活性

物理化学性质&存储条件

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