Chemical Structure : TGN1412
CAS No.:
货号: PC-Ab1030Not For Human Use, Lab Use Only.
TGN1412 is a novel superagonist anti-CD28 monoclonal antibody that directly stimulates T cells. TGN1412 binds to the laterally exposed C′D loop of CD28 and demonstrated its therapeutic potential for use in autoimmune disease, led to a massive and uncontrolled release of proinflammatory cytokines (cytokine storm) during clinical phase I trials..
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1 mg | ¥3580 | In stock | |
5 mg | ¥7580 | In stock | |
10 mg | ¥12800 | In stock | |
100 mg | Get quote |
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TGN1412 is a novel superagonist anti-CD28 monoclonal antibody that directly stimulates T cells. TGN1412 binds to the laterally exposed C′D loop of CD28 and demonstrated its therapeutic potential for use in autoimmune disease, led to a massive and uncontrolled release of proinflammatory cytokines (cytokine storm) during clinical phase I trials.
分子量 | ||
分子式 | Human IgG4P-Kappa | |
外观性状 | Solid | |
储存条件 |
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Solubility |
PBS, pH 7.0 Contains no stabilizers or preservatives |
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Chemical Name/SMILES |
TGN1412; TGN 1412; TGN-1412; TP44; T-cell-specific surface glycoprotein CD28 |
1. 1, Suntharalingam G, et al. N Engl J Med. 2006 Sep 7;355(10):1018-28. 2, Dayan CM, et al. Clin Exp Immunol. 2008 Feb;151(2):231-4. 3, Eastwood D, et al. Br J Pharmacol. 2010 Oct;161(3):512-26. 4, Panoskaltsis N, et al. Cancer Immunol Immunother. 2021 Apr;70(4):1127-1142.
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