TG8-260 | EP2 antagonist | Probechem Biochemicals

Chemical Structure : TG8-260

CAS No.: 2490544-50-6

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TG8-260 (TG 8-260)

货号: PC-72851Not For Human Use, Lab Use Only.

TG8-260 is a second-generation, potent, selective EP2 antagonist with Schild KB of 13.2 nM.

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10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

TG8-260 is a second-generation, potent, selective EP2 antagonist with Schild KB of 13.2 nM.
TG8-260 displays 500-fold selectivity to EP2 against other prostanoid receptors.
TG8-260 has a plasma half-life of 2.14 h (PO) and excellent oral bioavailability (77.3%), TG8-260 is a potent inhibitor of CYP450 enzymes.
TG8-260 displays antagonistic activity on the induction of EP2 receptor-mediated inflammatory gene expression in microglia BV2-hEP2 cells.
TG8-260 reduces hippocampal neuroinflammation and gliosis after pilocarpine-induced status epilepticus in rats.
TG8-260 is a tool for investigating anti-inflammatory pathways in peripheral inflammatory disease animal models.

物理化学性质&存储条件

分子量	344.418
分子式	C21H20N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(1H-imidazol-4-yl)-N-(2-(2-methyl-1H-indol-3-yl)ethyl)benzamide

参考文献

1. Radhika Amaradhi, et al. ACS Pharmacol Transl Sci. 2022 Jan 25;5(2):118-133.

TG8-260 (TG 8-260)

生物&药学活性

物理化学性质&存储条件

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TG8-260 (TG 8-260)

生物&药学活性

物理化学性质&存储条件

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