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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cdc2-like Kinase (CLK)-TG693
TG693

Chemical Structure : TG693

CAS No.: 885272-55-9

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TG693 (TG-693;TG 693)

货号: PC-61023Not For Human Use, Lab Use Only.

TG693 is an orally available, selective, ATP-competitive CLK1 inhibitor with IC50 of 112.6 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TG693 is an orally available, selective, ATP-competitive CLK1 inhibitor with IC50 of 112.6 nM.
TG693 also potently inhibits haspin activity and weakly inhibits DYRK kinases in a panel of 313 recombinant kinases.
TG693 promotes the skipping of the endogenous mutated exon 31 in DMD patient-derived cells and increases the production of the functional exon 31-skipped dystrophin protein.
TG693 inhibits the phosphorylation of CLK1 substrate serine/arginine-rich proteins and modulates pre-mRNA splicing in the skeletal muscle in mice.

物理化学性质&存储条件

分子量 195.225
分子式 C12H9N3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(pyridin-4-yl)-1H-indazole

参考文献

1. Sako Y, et al. Sci Rep. 2017 May 30;7:46126.

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