TG6-10-1 |CAS:1415716-58-3 Probechem Biochemicals

Chemical Structure : TG6-10-1

CAS No.: 1415716-58-3

加入收藏

TG6-10-1 (EP2 antagonist)

货号: PC-45111Not For Human Use, Lab Use Only.

TG6-10-1 is a potent and selective antagonist of prostaglandin E2 receptor subtype EP2 with Kb of 17.8 nM.

规格	价格	库存
10 mg	￥1580	In stock
25 mg	￥2580	In stock
50 mg	￥3980	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

TG6-10-1 is a potent and selective antagonist of prostaglandin E2 receptor subtype EP2 with Kb of 17.8 nM.
TG6-10-1 displays >300-fold selectivity over EP3, EP4, and IP receptors, 100-fold selectivity over EP1, 25-fold selectivity over FP and TP, and 10-fold selectivity over DP1 receptors.
TG6-10-1 completely recapitulates the effects of conditional ablation of COX-2 from principal forebrain neurons, accelerates recovery from weight loss, reduces brain inflammation, prevention of blood-brain barrier opening, and neuroprotection in the hippocampus, without modifying seizures acutely in the mouse pilocarpine model of SE.

物理化学性质&存储条件

分子量	448.4349
分子式	C23H23F3N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Propenamide, N-[2-[2-(trifluoromethyl)-1H-indol-1-yl]ethyl]-3-(3,4,5-trimethoxyphenyl)-, (2E)-

参考文献

1. Jiang J, et al. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3591-6.

2. Rojas A, et al. Neuropharmacology. 2015 Jun;93:15-27.

3. Rojas A, et al. Neuropharmacology. 2016 Nov;110(Pt A):419-30.

TG6-10-1 (EP2 antagonist)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

TG6-10-1 (EP2 antagonist)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.