TG554 | mPGES-1 inhibitor | Probechem Biochemicals

Chemical Structure : TG554

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TG554 (TG-554)

货号: PC-22237Not For Human Use, Lab Use Only.

TG554 is a potent, selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor with IC50 of 5.6 nM, suppresses leukotriene (LT) biosynthesis at low µM concentrations.

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生物&药学活性

TG554 is a potent, selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor with IC50 of 5.6 nM, suppresses leukotriene (LT) biosynthesis at low µM concentrations.
TG554 does not inhibit other essential enzymes in the AA cascade, namely 5-LOX, COX-1, and COX-2 at 10 uM.
TG554 significantly inhibits the generation of PGE2 with IC50 of 30 nM in stimulated M1-MDMs.
TG554 (10 uM) strongly impaires 5-LOX product biosynthesis in ionophore-activated neutrophils.

物理化学性质&存储条件

分子量	440.28
分子式	C22H15Cl2N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Chloro-N-(5-{4-[(4-chlorophenyl)methoxy]phenyl}-1,3,4-oxadiazol-2-yl)benzamide

参考文献

1. Tuğçe Gür Maz, et al. Bioorg Chem. 2024 Apr 16:147:107383.

TG554 (TG-554)

生物&药学活性

物理化学性质&存储条件

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TG554 (TG-554)

生物&药学活性

物理化学性质&存储条件

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