TG 100801 hydrochloride |CAS:1018069-81-2 Probechem Biochemicals

Chemical Structure : TG 100801 hydrochloride

CAS No.: 1018069-81-2

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TG 100801 hydrochloride (TG100801 Hydrochloride;TG-100801 Hydrochloride)

货号: PC-42434Not For Human Use, Lab Use Only.

The prodrug of TG 100572, a potent, dual receptor tyrosine kinase/Src kinase inhibitor with IC50 of 2-16 nM for VEGFR, FGFR and PDGFR, 0.1-5 nM for Src family.

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10 mg	￥3040	In stock
50 mg	￥7680	In stock
100 mg		Get quote

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生物&药学活性

The prodrug of TG 100572, a potent, dual receptor tyrosine kinase/Src kinase inhibitor with IC50 of 2-16 nM for VEGFR, FGFR and PDGFR, 0.1-5 nM for Src family; significantly suppresses laser-induced CNV in mice, and reduces fluorescein leakage from the vasculature and retinal thickening in a rat model of retinal vein occlusion (topical administration).

物理化学性质&存储条件

分子量	616.5369
分子式	C33H31Cl2N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Phenol, 4-chloro-3-[5-methyl-3-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-1,2,4-benzotriazin-7-yl]-, 1-benzoate, hydrochloride (1:1)

参考文献

1. Doukas J, et al. J Cell Physiol. 2008 Jul;216(1):29-37.

2. Sharma S, et al. J Virol. 2011 Jun;85(12):5995-6007.

3. Palanki MS, et al. J Med Chem. 2008 Mar 27;51(6):1546-59.

TG 100801 hydrochloride (TG100801 Hydrochloride;TG-100801 Hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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TG 100801 hydrochloride (TG100801 Hydrochloride;TG-100801 Hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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