TG003 | CLK inhibitor | Probechem Biochemicals

Chemical Structure : TG003

CAS No.: 719277-26-6

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TG003 (TG-003)

货号: PC-72778Not For Human Use, Lab Use Only.

TG003 (TG-003) is a potent, specific, reversible, and ATP-competitive inhibitor of Cdc2-like kinase (CLK) with IC50 of 20, 200 and 15 nM for mClk1, 2 and 4 respectively, and >10 uM for mClk3

规格	价格	库存
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg	￥5580	In stock
1 g		Get quote

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生物&药学活性

TG003 (TG-003) is a potent, specific, reversible, and ATP-competitive inhibitor of Cdc2-like kinase (CLK) with IC50 of 20, 200 and 15 nM for mClk1, 2 and 4 respectively, and >10 uM for mClk3.
TG003 inhibited SF2/ASF-dependent splicing of beta-globin pre-mRNA in vitro by suppression of Clk-mediated phosphorylation.
TG003 also suppressed serine/arginine-rich protein phosphorylation, dissociation of nuclear speckles, and Clk1/Sty-dependent alternative splicing in mammalian cells.

物理化学性质&存储条件

分子量	249.329
分子式	C13H15NO2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-1-(3-ethyl-5-methoxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one

参考文献

1. Carrillo García C, et al. J Med Chem. 2022 Jan 27;65(2):1505-1524.

2. Uzor S, et al. Sci Rep. 2021 Apr 12;11(1):7963.

3. Sako Y, et al. Sci Rep. 2017 May 30;7:46126.

4. Muraki M, et al. J Biol Chem. 2004 Jun 4;279(23):24246-54.

TG003 (TG-003)

生物&药学活性

物理化学性质&存储条件

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TG003 (TG-003)

生物&药学活性

物理化学性质&存储条件

参考文献

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