TG-6304 | DCN3 inhibitor | Probechem Biochemicals

Chemical Structure : TG-6304

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TG-6304 (TG6304)

货号: PC-72009Not For Human Use, Lab Use Only.

TG-6304 (TG6304) is a first-in-class, potent, highly selective, cell-permeable DCN3 inhibitor with Ki of 35 nM, does not bind to DCN1 at 30 uM.

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生物&药学活性

TG-6304 (TG6304) is a first-in-class, potent, highly selective, cell-permeable DCN3 inhibitor with Ki of 35 nM, does not bind to DCN1 at 30 uM.
TC-6304 engages DCN3 in cells in a dose-dependent manner but does not affect the neddylation of any of the cullins.
TC-6304 effectively enhances the thermal stability of cellular DCN3 protein in a dose-dependent manner and has no significant effect on the thermal stability of cellular DCN1 protein (10-1000 nM).

物理化学性质&存储条件

分子量	583.139
分子式	C31H33ClF2N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-(5-(3-chlorophenyl)-4-methylthiazol-2-yl)-2-((3,5-difluorophenyl)amino)-N-((S)-1-(dimethylamino)-3-(p-tolyl)propan-2-yl)propanamide

TG-6304 (TG6304)

生物&药学活性

物理化学性质&存储条件

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TG-6304 (TG6304)

生物&药学活性

物理化学性质&存储条件

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